Signal dynamics in Sonic hedgehog tissue patterning
نویسندگان
چکیده
منابع مشابه
Signal dynamics in Sonic hedgehog tissue patterning.
During development, secreted signaling factors, called morphogens, instruct cells to adopt specific mature phenotypes. However, the mechanisms that morphogen systems employ to establish a precise concentration gradient for patterning tissue architecture are highly complex and are typically analyzed only at long times after secretion (i.e. steady state). We have developed a theoretical model tha...
متن کاملRole of neuroepithelial Sonic hedgehog in hypothalamic patterning.
The hypothalamus is a region of the diencephalon with particularly complex patterning. Sonic hedgehog (Shh), encoding a protein with key developmental roles, shows a peculiar and dynamic diencephalic expression pattern. Here, we use transgenic strategies and in vitro experiments to test the hypothesis that Shh expressed in the diencephalic neuroepithelium (neural Shh) coordinates tissue growth ...
متن کاملPatterning the dorsal telencephalon: a role for sonic hedgehog?
Division of the telencephalic vesicle into hemispheres and specification of the cerebral cortex are key stages in forebrain development. We investigate the interplay in these processes of Sonic hedgehog (Shh), fibroblast growth factors (Fgfs), and the transcription factor Gli3, which in its repressor form (Gli3R) antagonizes Shh signaling and downregulates expression of several Fgf genes. Contr...
متن کاملSonic hedgehog regulates the growth and patterning of the cerebellum.
The molecular bases of brain development and CNS malignancies remain poorly understood. Here we show that Sonic hedgehog (Shh) signaling controls the development of the cerebellum at multiple levels. SHH is produced by Purkinje neurons, it is required for the proliferation of granule neuron precursors and it induces the differentiation of Bergmann glia. Blocking SHH function in vivo results in ...
متن کاملSonic hedgehog in CNS development: one signal, multiple outputs.
Sonic hedgehog (SHH) is a member of the hedgehog family of signalling molecules. SHH was initially described as a protein secreted from two signalling centres, the notochord and the floor plate. Subsequently, it was identified as a morphogen that is directly responsible for dorso-ventral patterning of the CNS. More recently, additional sites of SHH expression have been identified and multiple a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Development
سال: 2006
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.02337